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دانلود پاورپوینت پزشکی ( اختلال متابولیسم کربوهیدرات carbohydrate metabolism disroder )
(۴۹ اسلاید انگلیسی)
Step: 1
Galactokinase reaction:
Galactose is first phosphorylated by galactokinase to galactose -1- phosphate
Step: 2
Galactose -1- phosphate uridyl transferase
This is the rate limiting enzyme.
Galactose is not an essential nutrient since UDP-glucose can be converted to UDP – galactose by the enzyme UDP-hexose 4- epimerase and requires NAD+
Galactose is not essential in diet
Due to the block in this enzyme, galactose 1- phosphate will accumulate in liver.
This will inhibit galactokinase as well as glycogen phosphorylase
It results in hypoglycemia.
Galactose cannot be converted to glucose
Increased galactose level increases insulin secretion, which lowers blood glucose level.
G6PD deficiency is the most common disease producing enzyme abnormalities in humans, affecting more than 200 million individuals worldwide.
The highest prevalence in the Middle East, tropical Africa & Asia.
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